Acyclovir Tablets

Subject = Herpes Treatment
Description = Acyclovir has an antiviral effect on herpes simplex viruses and varicella zoster virus
Category = Health

Acyclovir 400mg and 800mg tablets

Presentation

GLOBAL ACYCLOVIR 400mg tablets are white, oval biconvex tablets identified ACY400 on one sideacyclovir, Acyclovir Tablets

Each tablet contains 400mg acyclovir and typically weighs 525mgacyclovir, Acyclovir Tablets

GLOBAL ACYCLOVIR 800mg tablets are white, oval biconvex tablets identified ACY800 on one side Acyclovir Tablets and a breakline on the otheracyclovir, Acyclovir Tablets

Each tablet contains 800mg acyclovir and typically weighs 1050mgacyclovir, Acyclovir Tablets

Uses

Actions

Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses, varicella-zoster virus, Epstein-Barr virus and to a lesser extent Acyclovir Tablets cytomegalovirusacyclovir, Acyclovir Tablets

Acyclovir has an antiviral effect on herpes simplex viruses and varicella zoster virus resulting from its interference with DNA synthesis leading to inhibition of virus replicationacyclovir, Acyclovir Tablets

The exact mechanism of acyclovir action in other susceptible viruses has not been fully elucidatedacyclovir, Acyclovir Tablets

Acyclovir triphosphate is Acyclovir Tablets the pharmacologically active metabolite of the drugacyclovir, Acyclovir Tablets

The initial phosphorylation of acyclovir to acyclovir monophosphate is catalysed by virus-induced thymidine kinaseacyclovir, Acyclovir Tablets

Thus selective activation of the drug is achieved principally in infected cellsacyclovir, Acyclovir Tablets

Further phosphorylation to acyclovir diphosphate is catalysed via cellular guanylate kinase and then phosphorylation Acyclovir Tablets to acyclovir triphosphate is catalysed via other intracellular enzymes (phosphoglycerate kinase, pyruvate kinase, phosphoenolpyruvate carboxykinase) acyclovir, Acyclovir Tablets

The extent of formation of acyclovir monophosphate, diphosphate and triphosphate is directly related to the concentration of acyclovir in the cellular culture mediumacyclovir, Acyclovir Tablets

In vitro studies indicate that acyclovir tri-phosphate is produced Acyclovir Tablets in low concentrations via unidentified cellular phosphorylating enzymes in cells infected with Epstein-Barr virus and cytomegalovirusacyclovir, Acyclovir Tablets

Acyclovir triphosphate inhibits DNA synthesis by competing with deoxyguanosine triphosphate for viral DNA polymeraseacyclovir, Acyclovir Tablets

Viral DNA polymerase exhibits a 10- to 30-fold greater affinity for acyclovir triphosphate than does cellular ?-DNA Acyclovir Tablets polymeraseacyclovir, Acyclovir Tablets

Following incorporation of acyclovir triphosphate into the growing viral DNA chain, DNA synthesis is terminatedacyclovir, Acyclovir Tablets

Cytomegalovirus does not produce thymidine kinase and so the antiviral activity of acyclovir in cytomegalovirus-induced infections is pooracyclovir, Acyclovir Tablets

The selective action of acyclovir on the infected cells is due to poor Acyclovir Tablets uptake of acyclovir into uninfected cells, minimal phosphorylation of acyclovir to acyclovir monophosphate in uninfected cells and low cellular DNA polymerase affinity for acyclovir triphosphate.